Mullis acquired a reputation for erratic behavior at Cetus, once threatening to bring a gun to work; he also engaged in “public lovers’ quarrels” with his then-girlfriend (a fellow chemist at the company) and “nearly came to blows with another scientist” at a staff party, according to California Magazine. White recalled: “It definitely put me in a tough spot. His behavior was so outrageous that the other scientists thought that the only reason I didn’t fire him outright was that he was a friend of mine.”

After resigning from Cetus in 1986, Mullis served as director of molecular biology for Xytronyx, Inc. in San Diego for two years. While inventing a UV-sensitive ink at Xytronyx, he became skeptical of the existence of the ozone hole.

And he only goes downhill from there…