Nah, plenty of cult classics failed when they came out, but would be impossible to create at the time they became popular. So if you have an artistic vision and an opportunity to realize it, it doesn’t matter if the masses are ready for it, you should go for it. If the goal was creating a musical with Lady Gaga and Joaquin Phoenix, the time was now and the result is at least interesting enough to be culturally viable. We’ll have to check in 20 years to see if it has any staying power as a cult classic.
I do know much about anime and these are all mainstream anime I could think of in 10 seconds:
They’re humans with some animal features, so none of the above would count as bestiality. I don’t think a fantasy involving a werewolf and a fancy dildo is anywhere near bestiality either, so maybe don’t judge people for a little kink.