No idea about AMD but I have nvidia 3070 and works just fine. I use gnome for gaming and kde works well too. No settings changed, simple archinstall script with nvidia proprietary drivers and steam.
I’m not sure why but xfce multi screen gaming is problematic, haven’t dived into it.
Not saying don’t get AMD but nvidia has horrible reputation which is kinda unfair nowadays. Their driver has improved a lot.
I’ve been using arch and manjaro for the past 3 years with awesomewm and gnome (can’t get awesomewm to behave with second monitor while gaming so I switch to gnome when using the second monitor, using laptop) and this has pretty much been my experience. Windows is bloated and it never"just works".